Tottenham have taken up residence at Wembley for the season while their new stadium is built in North London. However, it is no secret that Tottenham struggled to adapt to their new home in European competition last term.
Mauricio Pochettino's side only win at the national stadium in the Champions League Group stage last season came in a meaningless match against CSKA Moscow.
Spurs will be looking to put their poor Wembley performances behind them and continue their bright start to the Premier League against Chelsea.
Antonio Conte's side will be looking to kick-start their campaign after a shock 3-2 home defeat to Burnley on the opening weekend of the new Premier League season.
The Blues will be going into the match with the knowledge that they won the most recent matchup at Wembley with a 4-2 victory in the FA Cup semi-final.
As we look ahead to the meeting, which stars would make it into your combined starting XI? Here is a potential line-up:
Goalkeeper: Thibaut Courtois
Centre-Back: Toby Alderweireld
Centre-Back: David Luiz
Centre-Back: Jan Vertonghen
Right Wing-Back: César Azpilicueta
Central Midfielder: Christian Eriksen
Central Midfielder: N'Golo Kanté
Left Wing-Back: Danny Rose
Attacking Midfielder: Dele Alli
Striker: Álvaro Morata
Striker: Harry Kane