Due to an accumulation of yellow cards, Luis Suarez will be unable for selection which means head coach Ernesto Valverde will have to utilise his other attacking options against Bilbao at the Camp Nou on Sunday.
It will be the first game in 13 matches in which the Uruguayan will not feature and his 10 goals during that period will, therefore, be a big miss.
The last time Suarez missed a game was at the RCDE Stadium, against Espanyol in the quarter-finals of the Copa del Rey, which 'Los Cules' lost 1-0.
Valverde will be hoping that isn't an omen for Sunday's game as he turns to new signings Dembele and Coutinho to fill the void left by his main striker, who has contributed 21 goals this season.
It will be a tough task, but the two newcomers are starting to find their feet at the Camp Nou and have both already scored their first goal for the club so will be hoping to improve their tallies in Suarez's absence in a newly-formed 'DMC'.