Tottenham: New boy Lucas Moura will be available to make his debut in the game, whilst Toby Alderweireld, Harry Winks, Serge Aurier and Danny Rose are all in contention after they returned from injury in the FA Cup win over Newport in midweek.
Arsenal: Goalkeeper Petr Cech is a doubt with a calf problem, meaning David Ospina may start. Striker Danny Welbeck could be fit to feature in the game after a groin issue, whilst Nacho Monreal could start after shrugging off a bout of illness.
Tottenham boss Mauricio Pochettino on their chances of finishing second:
"I'm a person that believes, and of course we're going to fight for that to happen.
"The [seven-point] gap is not massive but it will be tough."
Arsenal boss Arsene Wenger:
"It is always a game that is charged emotionally. This season, if you look at the table, it is a very important game.
"For us, it is an opportunity to come back closer to the Champions League places, which is a priority.
"We lost our last two away games, at Bournemouth where we were 1-0 up, at Swansea where we were 1-0 up. You look at the mistakes we made and I am quite optimistic we will not make them again."
Did you know?
The two side have met 194 times in all competitions, with Arsenal leading the way with 81 wins to Tottenham's 62.
Form:
Possible lineups:
Tottenham: Lloris; Trippier, Alderweireld, Vertonghen, Davies; Dier, Dembele; Eriksen, Alli, Son; Kane.
Arsenal: Ospina; Bellerin, Koscielny, Mustafi, Monreal; Xhaka, Wilshere; Ramsey, Ozil, Mkhitaryan; Aubameyang.